Mesothelioma and Non Asbestos Exposure Mesothelioma most commonly develops in the lining of the lungs (pleura) and abdomen (peritoneum). This rare cancer can also develop in the linings around the heart or the testes (pericardium). Asbestos exposure is the primary risk factor for mesothelioma. Some people with mesothelioma do not have a history of asbestos exposure.
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