Mesothelioma and Asbestos Exposure Exposure to asbestos at work is the main reason for mesothelioma. The exposure to asbestos can happen in shipyards, construction sites and factories. Inhaled asbestos fibres get trapped in the lung's lining (pleura) and cause gene mutations that can result in cancer. The symptoms typically don't appear until 20 to 60 years after exposure.
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